Astragalus Root Extract
Product name :astragalus membranaceus extract
Botanical Name :Astragalus membranaceus
Active ingredients :Astragaloside ,polysaccharides, saponins, flavonoids
synonyms :Astragalus, Astragalus Root Extract, astragalus polysaccharide, SWANSON Astragalus Root,huangqi, (A component of) Danggui buxue tang (DBT), membranous milk-vetch root, ogi, Huang Qi, TA-65, TAT2
Appearance :Yellow brown
Part used :Root
Specification :10:1,Polysaccharide 20%,30%,50%, Astragaloside 0.5%-10%
Dosage :200 mg, twice a day
Main benefits :Immune support, anti-inflammatory, cardiovascular system improvement
Applied industries :Bodybuilding, supplements, preworkouts
What is astragalus membranaceus extract?
Astragalus membranaceus, as one of the important “Qi tonifying” adaptogenic herbs in Trational Chinese Medicine(TCM), has been used in China for thousand years. Astragalus Membranaceus is a perennial member of the flowering legume (pea) family. It is indigenous to the northern and eastern parts of China and Mongolia where the astragalus root has been used for several thousand years in a variety of herbal mixtures to treat everything from diseases of the heart, liver and kidneys, to viral infections, cancer and immune disorders. Chinese Medicine considers astragalus herb to be one of the most important herbal tonics and as such it is valued for its ability to strengthen the primary energy of the body which we know as the immune system, as well as the metabolic, respiratory and eliminative functions. This fact is being increasingly substantiated by western research.
Astragalus first appeared in the west in the1800's, used by herbalists as a tonic and an ingredient in many herbal remedies. But it wasn't until the 1970's when research began to confirm it's abilities to stimulate the immune system and fight viruses and bacteria, subdue inflammation and protect the liver that it was brought it into popular use in the alternative medicine markets. There is evidence that this herb has far-reaching effects on the over all functioning and balance of the body, normalizing body functions and regenerating tissues.
Chemical constituents of Astragalus membranaceus extract:
The main constituents of Astragalus membranaceus include polysaccharides, saponins, flavonoids, amino acids, and trace elements.
Astragalus root contains a series of cycloartane triterpene glycosides denoted astragalosides I-VII (saponins), that are based on the aglycone cycloastragenol and contain from one to three sugars attached at the 3-, 6-, and 25-positions.5-8 In the predominant astragalosides I-III, the 3-glucose is acetylated. Several saponins have also been reported that are based on the oleanene skeleton.
Using high performance liquid chromatography-electrospray ionization mass spectrometry to analyze the flavonoids in the roots of Astragalus membranaceus and Astragalus mongholicus, eight flavonoids were identified,including calycosin-7-O-beta-D-glucoside, calycosin-7-O-beta-D-glucoside-6'-O-malonate(2), ononin, (6aR,11aR)-3-hydroxy-9,10-dimethoxypterocarpan-3-O-beta-D-glucoside,calycosin,(3R)-7,2'-dihydroxy-3',4'-dimethoxyisoflavan-7-O-beta-D-glucoside, formononetin-7-O-beta-D-glucoside-6'-O-malonate, and formononetin.
Phytosterols, a volatile oil, and amino acids, including gamma-aminobutyric acid(GABA) and L-canavanine, have been isolated from the root.11 Zinc, iron, copper, magnesium, manganese, calcium, potassium, sodium, cobalt, rubidium, molybdenum, chromium, vanadium, tin, and silver have also been found in the root of Astragalus, as well as traces of tantalum, hafnium, europium, and thorium. Organic compounds identified in the roots include choline, betaine, gluconic acid, and β-sitosterols, as well as aromatic compounds, essential oil, linoleic acid, α-aminobutyric acid, bitter compounds, and asparagine.
How astragalus membranaceus extract Works
Research shows Astragalus root stimulates the immune system in many ways. It increases the number of stem cells in bone marrow and lymph tissue and encourages their development into active immune cells. It appears to help trigger immune cells from a “resting” state into heightened activity. One study showed Astragalus root helps promote and maintain respiratory health. It also enhances the body’s production of immunoglobulin and stimulates macrophages. Astragalus can help activate T-cells and natural killer (NK) cells.
Several studies also show Astragalus proffers heart-protecting effects, including protection against oxidative damage. Additionally, the flavonoids, saponins, and polysaccharides found in Astragalus root help minimize free radical damage to membranes.
The flavonoids and saponins in Astragalus can significantly inhibit membrane lipid peroxidation generated by superoxide (O2-), hydrogen peroxide (H2O2), and ultraviolet rays, whilethe polysaccharides of Astragalus possess weaker protective activity.
Astragalus has been shown to have inhibitory effects on lipid peroxidation and protein oxidative modification by copper. The results of a study showed the free radical scavenging effects were similar to, and stronger than, those of mannitol and superoxide dismutase, respectively, demonstrating inhibitory effects on oxidative stress induced by copper.
The constituents of the root include: polysaccharides, flavonoids, Triterpene gylcosides and amino acids. The polysaccharides provide a powerful antioxidant effect, fighting the cellular damage caused by free radicals.
Astragalus root increase the number of stem cells in lymph tissue and bone marrow, and encourages their development into active immune cells. It is also known to stimulate the body’s natural production of interferon and immunoglobulin. It stimulates white blood cell (macrophage) activity, T cell, NK cell and promotes adrenal cortical function.
Over all Astragalus appears to provide the support components to help normalize body defense functions. And while it has not shown anti-tumoral activity, it actively stimulates those components which are most instrumental in the body's own fight against cancer.
Benefits of taking Astragalus membranceus supplement:
Astragalus membranaceus extract has been widely used in the nutrition, supplement, and bodybuilding industries due to its benefitsof providing deep immune support,improving ability to respond and adapting to stress (Adaptogen),Improving energy and vitality and recovery rate. Some main key benefits are summariezed as below:
Strengthen Immune System
Astragalus membranceus extract’s primary function is as an immune stimulator supporting and enhancing the body's own defense system while controlling autoimmune issues. Astragalus stimulates the production of T cell, Natural Killer (NK) cell, macrophages, immunoglobulin, interferon all important function that the body uses to fight viruses.
Antibacterial and anti-inflammatory properties
It is sometimes used on the skin for wounds. In addition, studies have shown that astragalus has antiviral properties and stimulates the immune system, suggesting that it may help prevent colds.
Cardiovascular system improvement
There is also evidence for cardiovascular system improvement, particularly in clinical parameters associated with angina, congestive heart failure and acute myocardial infarct. This may be due to the herb's antioxidant activity. Its use in the treatment of hepatitis in modern Chinese medicine is supported by the demonstration of hepatoprotective activity in animal studies.
Reduction of Fatigue in Athletes
Herbal extracts containing astragalus may help athletes utilize oxygen, thereby reducing their fatigue. Because astragalus is an adaptogen, it can also help the body adapt to the physical stress brought on by exercise.
Are There Side Effects With Astragalus?
Astragalus is usually taken in combination with other herbal supplements. When used appropriately, astragalus appears to be very safe and to have few side effects. Very high doses may suppress the immune system. So you should avoid using astragalus if you are taking immune-suppressing drugs.
Pregnant or nursing women should not use astragalus root. If you have an immune system disease such as multiple sclerosis, lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis, or another condition known as an "autoimmune disease," you should not use astragalus root. As with any herbal supplement, always check with your health care provider before taking astragalus root.
Dosage of Astragalus membranceus extract
The appropriate dose of astragalus depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for astragalus. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.